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Description
GCLC Recombinant Rabbit mAb (S-2198-137)Product Specification Host Rabbit Antigen GCLC Synonyms Glutamate cysteine ligase catalytic subunit; GCS heavy chain; Gamma ECS; Gamma glutamylcysteine synthetase; GLCL; GLCLC Immunogen Synthetic Peptide Location Mitochondrion Accession P48506 Clone Number S 2198 137 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample MCF7, A549 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | GCLC |
| Synonyms | Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase; GLCL; GLCLC |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P48506 |
| Clone Number | S-2198-137 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | MCF7, A549 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The GCLC (glutamate–cysteine ligase catalytic subunit) protein is the catalytic subunit of glutamate cysteine ligase (GCL, formerly γ-glutamylcysteine synthetase), the enzyme that catalyzes the first, rate-limiting step in glutathione (GSH) synthesis by forming γ-glutamylcysteine from glutamate and cysteine using ATP; this ~73 kDa subunit contains all substrate and cofactor binding sites necessary for catalysis, while the regulatory GCLM subunit increases its catalytic efficiency when complexed in the holoenzyme, and mutations in GCLC are associated with hemolytic anemia due to GSH deficiency and susceptibility to myocardial infarction [^5].
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